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The penetrance also differs for each MMR gene; and the average cumulativerisk of colorectal cancer to age 70 years (95 % con?dence intervals) for MLH1 andMSH2 mutation carriers were estimated to be 34 % (25–50 %) and 47 % (36–60 %) respectively, for males and 36 % (25–51 %) and 37 % (27–50 %), respec-tively, for females suggesting that even within carriers there is considerableheterogeneity of effect [ 36]. Your appearance, demeanor, posture, facial expres-sions, and attitude strongly in?uence how the client perceivesthe questions you ask.