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Moreattention has been paid to the role of inflammatory effects,which has been observed in animal exposure studies.Following O exposure, the bronchoalveolar lavage fluidshowed an increase in proinflammatory cytokines, polymor-phonuclear leukocytes, together with arachidonic acid descen-dants, such as the prostaglandins (thromboxane B , PGE , andPGF ). These mixed dimer TCR were a direct result of the pairing of transduced TCR-alpha or beta chains associating with endogenous TCR alpha or beta chains.

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